Baltimore is the most populous city in the state of Maryland, the fourth most populous city in the Mid-Atlantic, and the 30th most populous city in the United States with a estimated population of 595,218 in 2023. Baltimore was designated an independent city by the Constitution of Maryland in 1851, and today it is the most populous independent city in the nation. As of 2023, the population of the Baltimore metropolitan area was estimated to be 2,921,051, making it the nation's 20th largest metropolitan area. Baltimore is located about 40 miles (64 km) north northeast of Washington, D.C., making it a principal city in the Washington–Baltimore combined statistical area (CSA), the third-largest CSA in the nation, with a 2023 estimated population of 10,042,122.

Johns Hopkins Hospital and Johns Hopkins University are the city's top two employers. Baltimore and its surrounding region are home to the headquarters of a number of major organizations and government agencies, including the NAACP, ABET, the National Federation of the Blind, Catholic Relief Services, the Annie E. Casey Foundation, World Relief, the Centers for Medicare & Medicaid Services, and the Social Security Administration. Baltimore is also home to the Baltimore Orioles of Major League Baseball and the Baltimore Ravens of the National Football League.

In 1992, the Baltimore Orioles baseball team moved from Memorial Stadium to Oriole Park at Camden Yards, located downtown near the harbor. Pope John Paul II held an open-air mass at Camden Yards during his papal visit to the United States in October 1995. Three years later the Baltimore Ravens football team moved into M&T Bank Stadium next to Camden Yards. By 2010, the organization's region of service had expanded from merely Baltimore to include all of the Eastern Shore of Maryland.

Baltimore has seen the reopening of the Hippodrome Theatre in 2004, the opening of the Reginald F. Lewis Museum of Maryland African American History & Culture in 2005, and the establishment of the National Slavic Museum in 2012. On April 12, 2012, Johns Hopkins held a dedication ceremony to mark the completion of one of the United States' largest medical complexes – the Johns Hopkins Hospital in Baltimore.

On September 19, 2016, the Baltimore City Council approved a $660 million bond deal for the $5.5 billion Port Covington redevelopment project championed by Under Armour founder Kevin Plank and his real estate company Sagamore Development. Port Covington surpassed the Harbor Point development as the largest tax-increment financing deal in Baltimore's history and among the largest urban redevelopment projects in the country. The waterfront development that includes the new headquarters for Under Armour, as well as shops, housing, offices, and manufacturing spaces is projected to create 26,500 permanent jobs with a $4.3 billion annual economic impact. Goldman Sachs invested $233 million into the redevelopment project.

Many of Baltimore's neighborhoods have rich histories. The city is home to some of the earliest National Register Historic Districts in the nation, including Fell's Point, Federal Hill, and Mount Vernon. These were added to the National Register between 1969 and 1971, soon after historic preservation legislation was passed. Baltimore has more public statues and monuments per capita than any other city in the country. Nearly one third of the city's buildings (over 65,000) are designated as historic in the National Register, which is more than any other U.S. city, Baltimore has 66 National Register Historic Districts and 33 local historic districts. The historical records of the government of Baltimore are located at the Baltimore City Archives.